dopamine β-hydroxylase — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T19654	Guanoclor	VATENSOL	Others
	Guanoclor (VATENSOL) (INN), also known as guanochlor, is a sympatholytic drug. It is known to bind to non-adrenergic sites in pig kidney membranes.		Others
T13383	Zamicastat	BIA 5-1058	BCRP , Hydroxylase , P-gp
	Zamicastat (BIA 5-1058) is an inhibitor of dopamine β-hydroxylase (DBH), and is also a concentration-dependent dual inhibitor of P-gp and BCRP(IC50 values of 73.8 μM and 17.0 μM, respectively).		BCRP , Hydroxylase , P-gp
T6S0923	Hypericin	Hypericine,Cyclosan	Apoptosis , Antiviral , Influenza Virus , Tyrosine Kinases , Antibacterial , PKC
	1. Hypericin (Cyclosan) has antineoplastic activity. 2. Hypericin has antibiotic and antiviral activities. 3. Hypericin has antidepressive activity through inhibiting monoamine oxidase enzyme. 4. Hypericin inhibits RANKL...
T6604	Nepicastat hydrochloride	Nepicastat HCl,RS-25560-197 hydrochloride,SYN-117 hydrochloride,Nepicastat (SYN-117) HCl	Hydroxylase
	Nepicastat hydrochloride (RS-25560-197 hydrochloride) is an effective and specific inhibitor, which is used for bovine and human dopamine-β-hydroxylase with IC50 of 8.5 nM and 9 nM, respectively.The affinity of Nepicasta...		Hydroxylase
T61214	EWP 815		Phosphatase , Hydroxylase
	EWP 815 is a disulfiram analogue that functions as a powerful inhibitor of Ins(1,4) P 2 phosphatase, Ins(1,4,5) P 3 5-phosphatase, and dopamine β-hydroxylase activity [1] [2].		Phosphatase , Hydroxylase
T11238L	Etamicastat hydrochloride	BIA 5-453 hydrochloride	Dehydrogenase
	Etamicastat hydrochloride (BIA 5-453 hydrochloride) is a peripherally selective dopamine beta-hydroxylase inhibitor that reduces hypertension.		Dehydrogenase
T10146	4-Hydroxyderricin		Dehydrogenase , MAO
	4-Hydroxyderricin, a potent and selective MAO-B inhibitor (IC50: 3.43 μM), is the main active ingredient of Angelica sinensis, which mildly inhibits dopamine β-hydroxylase (DBH) activity and possesses antidepressant acti...		Dehydrogenase , MAO
T50049	4-Methylhistamine hydrochloride		Others
	4-Methylhistamine hydrochloride has been shown to inhibit the activity of copper-dependent enzymes such as tyrosinase and dopamine beta-hydroxylase and has also been shown to modulate the expression of genes involved in ...		Others
T71942	3-Allylphenol
	3-Allylphenol is an inhibitor of dopamine β-hydroxylase (DBH; Ki = 12 mM).
T11238	Etamicastat	BIA 5-453	Dehydrogenase
	Etamicastat can be used in the research of cardiovascular diseases. Etamicastat (BIA 5-453) is a potent and reversible dopamine-β-hydroxylase (DBH) inhibitor with an IC50 value of 107 nM.		Dehydrogenase
T60633	Nepicastat
	Nepicastat (SYN117) is a selective, potent, and orally active dopamine-beta-hydroxylase inhibitor which can cross the blood-brain barrier (BBB). Nepicastat (SYN117) produces concentration-dependent inhibition of bovine a...
T36207	Methylspinazarin
	Methylspinazarin is a naphthoquinone bacterial metabolite that has been found in Streptomyces and is an inhibitor of catechol O-methyltransferase (COMT; IC50 = 0.8 μg/ml).1 It is selective for COMT over tyrosine hydroxyl...
T6356	(R)-Nepicastat HCl	RS-25560-198 HCl	Hydroxylase
	(R)-Nepicastat HCl (RS-25560-198 HCl), the R-enantiomer of Nepicastat HCl, is a potent and selective inhibitor with IC50 of 25.1 nM and 18.3 nM for bovine and human dopamine-β-hydroxylase, with negligible affinity for tw...		Hydroxylase